范田园 博士 副教授

电话/传真：82805123，邮箱：tianyuan_fan@bjmu.edu.cn

    自1983年在北京大学药学院学习和工作，期间先后获得学士、硕士和博士学位，曾分别到香港中文大学和日本星药科大学访问学习。从事药剂学的教学、科研和开发工作。教学：讲授本科生和研究生课程，包括《药剂学》、《生物药剂学与药物动力学》、《药物输送系统》和《高等药物动力学》等；参编多部教材；2004年起任硕士生导师。科研：主要包括国务院批准的“重大新药物创制”大平台、“新制剂与新释药系统技术”平台、国家自然科学基金、北京市自然科学基金、北大方正基金和专利技术转让等项目。研究方向：转化医学给药系统，涉及栓塞给药系统、诊断/治疗肿瘤的靶向给药系统和3D打印给药系统等跨学科合作研究。成果：在中外期刊上发表论文50余篇，申请发明专利14项（已授权12项），研发的2种栓塞制剂获批生产，填补了国内空白并销往国外，为近千家医院的数十万患者所用，国内市场占有率超过70%，累计销售达数亿元。2006年获杭州市科技进步二等奖，2012-2016连续5年获北京大学医学部发明专利奖，2016年获首届全国药学院校实验教改特等奖，2017年获北京大学教学优秀奖等。

代表性论文

1．TY Fan，SL Wei, WW Yan, DB Chen, J Li. An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating material and cross-linked polyvinylpyrrolidone in the core tablets. Journal of controlled release. 2001, 77:245-251 (第一作者).

2．Tianyuan Fan, Kozo Takayama, Yoshiyuki Hattori, Yoshie Maitani. Formulation optimization of paclitaxel carried by pegylated emulsions based on artificial neural network. Pharmaceutical Research. 2004, 21(9): 1692-1697 (第一作者).

3．Dai-Chao Cui, Wan-Liang Lu, Er-A Sa, Meng-Jie Gu, Xiao-Jing Lu, Tian-Yuan Fan*. Poly(acrylic acid) microspheres loaded with lidocaine: Preparation and characterization for arterial embolization. International Journal of Pharmaceutics. 2012, 436: 527– 535 (责任作者).

4．Xiao-Jing Lu, Yuan Zhang, Dai-Chao Cui, Wen-Jing Meng, Ling-Ran Du, Hai-Tao Guan, Zhuo-Zhao Zheng, Nai-Qi Fu, Tian-Shi Lv, Li Song, Ying-Hua Zou, Wan-Liang Lu, Tian-Yuan Fan*. Research of novel biocompatible radiopaque microcapsules for arterial embolization. International Journal of Pharmaceutics. 2013, 452: 211– 219 (责任作者).

5．Ling-Ran Du, Xiao-Jing Lu, Hai-Tao Guan, Yong-Jie Yang, Meng-Jie Gu, Zhuo-Zhao Zheng, Tian-Shi Lv, Zi-Guang Yan, Li Song, Ying-Hua Zou, Nai-Qi Fu, Xian-Rong Qi, Tian-Yuan Fan*. Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate. International Journal of Pharmaceutics. 2014, 471: 285– 296(责任作者).

6. Meng-Jie Gu, Kun-Feng Li, Lan-Xin Zhang, Huan Wang, Li-Si Liu, Zhuo-Zhao Zheng, Nan-Yin Han, Zhen-Jun Yang*,Tian-Yuan Fan*. In vitro study of novel gadolinium-loaded liposomesguided by GBI-10 aptamerfor promising tumor targeting and tumor diagnosis by magnetic resonance imaging. International Journal of Nanomedicine. 2015, 10: 5187-5204(责任作者).

7. Zi-Yuan Li, Xiao-Ya Qin, Li-Ying Guo, Huan Wang, Xiao-Xin Liu, Zhuo-Zhao Zheng, Hai-Tao Guan, Li Song, Ying-Hua Zou, Tian-Yuan Fan*. Poly (acrylic acid) microspheres loaded with superparamagnetic iron oxide nanoparticles for transcatheter arterial embolization and MRI detectability: in vitro and in vivo evaluation. International Journal of Pharmaceutics. 2017, 527: 31-41(责任作者).